Disease outbreak news: Dengue fever – Sao Tome and Principe (May 26, 2022) – Sao Tome and Principe


The situation at a glance

On May 13, 2022, the Ministry of Health (MoH) of São Tomé and Príncipe notified WHO of a dengue fever outbreak in São Tomé and Príncipe. From April 15 to May 17, 103 dengue fever cases and no deaths were reported. This is the first reported dengue fever outbreak in the country.

Description of the cases

From April 15 to May 17, 2022, 103 dengue cases, confirmed by rapid diagnostic test (RDT), and no deaths were reported in five health districts of São Tomé and Príncipe (Figure 1). The majority of cases (90.87%) were reported in the health district of Água Grande followed by Mézochi (7.7%), Lobata (4.4%); Cantagalo (1.1%); and Autonomous Region of Principe (1.1%) (Figure 2). The most frequently affected age groups were: 10-19 years (5.9 cases per 10,000), 30-39 years (7.3 cases per 10,000), 40-49 years (5.1 cases per 10 000) and 50-59 years (6.1 cases per 10,000). The most common clinical signs were fever (97.94%), headache (78.76%) and myalgia (64.62%).

A subset of 30 RDT-confirmed samples was sent to an international reference laboratory in Lisbon, Portugal, which was received on April 29. Further laboratory testing confirmed that the specimens were positive for early acute dengue infection and that the predominant serotype was dengue virus serotype 3 (DENV-3). Preliminary results suggest the possibility of other serotypes present in the sample batch.

A dengue outbreak alert was initially triggered when a suspected case of dengue fever was reported at a hospital in São Tomé and Príncipe on April 11. This case, who presented with symptoms suggestive of dengue infection, had a travel history and was later diagnosed as having previously been infected with dengue fever.

Disease epidemiology

Dengue fever is a viral infection transmitted to humans through the bite of infected mosquitoes. Dengue fever occurs in tropical and subtropical climates worldwide, primarily in urban and semi-urban areas. The main vectors of transmission of the disease are Aedes aegypti mosquitoes and, to a lesser extent, Ae. albopictus. The virus responsible for dengue fever is called dengue fever virus (DENV). There are four DENV serotypes and it is possible to be infected four times. Many DENV infections produce only mild disease and more than 80% of cases have no symptoms (asymptomatic). DENV can cause an acute flu-like illness. Sometimes this develops into a life-threatening complication called severe dengue fever.

There is no specific treatment for dengue fever; however, prompt case detection, identification of any warning signs of severe dengue, and appropriate case management are key elements of care to prevent patient deaths from dengue. A delay in seeking medical attention is often linked to deaths from dengue virus disease.

Occasional cases acquired abroad have been reported in people returning from an area with active dengue transmission, however, there is no conclusive evidence that there have been imported cases of dengue in São Tomé and Principe. Prior to this outbreak, São Tomé and Príncipe had never reported a dengue outbreak, despite being in the global dengue belt and having favorable conditions for dengue transmission.

Public health response

National health authorities have initiated and are undertaking the following measures in response to the outbreak:

  • Hold weekly meetings between the Ministry of Health and WHO to discuss technical aspects of the outbreak

  • Development, validation and dissemination of a dengue response plan

  • Conduct multidisciplinary epidemiological surveys and active case detection in several health districts

  • Conduct entomological surveys to identify breeding sites and conduct misting and source reduction measures in selected affected localities

  • Publication of a daily bulletin on the disease and regular sharing with the WHO

  • Organize deployments of external experts to build laboratory capacity in São Tomé and Príncipe, as well as other potential experts such as case management, risk communication, entomology and vector control

WHO risk assessment

The risk at the national level is currently assessed as high due to (i) the presence of the mosquito vector Aedes aegypti and Aedes albopictus; (ii) favorable environment for mosquito breeding sites following heavy rains and floods since December 2021; (iii) simultaneous outbreaks of diarrheal disease, malaria, COVID-19, among other health issues; and (iv) reduced functionality of sanitation and water management systems in health facilities due to structural damage after heavy flooding. Reported numbers are likely underestimated as a high proportion of dengue cases are asymptomatic and there are limitations to the ability to conduct surveillance and diagnose cases. The clinical management of severe dengue cases is also a challenge. Community awareness in the country is low and risk communication activities are insufficient.

The overall risk at regional and global levels is assessed as low. The likelihood of further spread from São Tomé and Príncipe to other countries is unlikely as the country is an island that does not share land borders and this would require the presence of susceptible vectors.

WHO Council

Case detection

  • It is important that health facilities have access to diagnostic tests to detect and/or confirm dengue cases.

  • Health centers on the outer islands of São Tomé and Príncipe should be notified of the outbreak and provided with RDTs to detect cases.

Vector management

  • Integrated vector management (IVM) activities should be strengthened to eliminate potential breeding sites, reduce vector populations and minimize personal exposure. This should include larval and adult vector control strategies, such as environmental management, source reduction and chemical control measures.

  • Vector control measures should be implemented in households, workplaces, schools and health facilities, among others, to prevent vector-person contact.

  • Community-supported source reduction measures should be initiated, as well as vector surveillance.

Individual protection measures

  • It is recommended to use protective clothing that minimizes skin exposure and to apply repellents that can be applied to exposed skin or clothing. Use of repellents should be strictly in accordance with label instructions.

  • Window and door screens and mosquito nets (whether or not impregnated with insecticide) can be useful in reducing vector-person contact in enclosed spaces day and night.

Travel and trade

  • WHO does not recommend any restrictions on travel and trade in São Tomé and Príncipe based on the information currently available.

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