Progress towards the control and elimination of neglected tropical diseases targeted by chemoprevention in São Tomé and Príncipe


This article was originally published here

Trans R Soc Trop Med Hyg. October 27, 2021: trab153. doi: 10.1093 / trstmh / trab153. Online ahead of print.


The government of São Tomé e Príncipe is committed to controlling and eliminating neglected tropical diseases (NTDs) as a public health problem by 2025. In 2014, the Ministry of Health conducted a national survey to determine the prevalence of soil-transmitted helminthiasis (STH) and schistosomiasis nationwide. Following this survey, a preventive chemotherapy (PC) campaign with mebendazole and praziquantel reached 31,501 school-aged children in 2015. A follow-up survey in 2017 to determine the impact of the intervention showed success in control of schistosomiasis, as no infection was found, but limited impact on HRTs, with similar prevalence at pretreatment levels. The survey also looked at the prevalence of a third NTD, lymphatic filariasis (LF), which was found to be endemic in the country. Since then, the Ministry of Health has developed the 2019-2025 Neglected Tropical Diseases Strategic Plan and identified the gaps to be filled. This narrative review systematizes the existing literature on the epidemiology of NTDs for which there are PC programs in São Tomé and Príncipe. PubMed was searched for relevant articles measuring the prevalence of LF, schistosomiasis and HRT. In addition, the data provided by the surveys of the Ministry of Health were analyzed. Finally, we discuss the current fight against NTDs, including the impact of the 2019 coronavirus disease pandemic and identify priorities for strengthening programs and operational research.

IDPM: 34718820 | DOI: 10.1093 / trstmh / trab153

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